Alternative Processing of the U2 Small Nuclear RNA Produces a 19–22nt Fragment with Relevance for the Detection of Non-Small Cell Lung Cancer in Human Serum

@inproceedings{Mazires2013AlternativePO,
  title={Alternative Processing of the U2 Small Nuclear RNA Produces a 19–22nt Fragment with Relevance for the Detection of Non-Small Cell Lung Cancer in Human Serum},
  author={Julien Mazi{\`e}res and Caroline Catherinne and Olivier Delfour and Sandrine Gouin and Isabelle Rouquette and M. -J. Delisle and Gr{\'e}goire Pr{\'e}v{\^o}t and Roger Escamilla and Alain Didier and David H. Persing and Mike Bates and B. Michot},
  booktitle={PloS one},
  year={2013}
}
RNU2 exists in two functional forms (RNU2-1 and RNU2-2) distinguishable by the presence of a unique 4-bases motif. Detailed investigation of datasets obtained from deep sequencing of five human lung primary tumors revealed that both forms express at a high rate a 19-22nt fragment (miR-U2-1 and -2) from its 3' region and contains the 4-bases motif. Deep sequencing of independent pools of serum samples from healthy donors and lung cancer patients revealed that miR-U2-1 and -2 are pervasively… CONTINUE READING