Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.

@article{Paschkowsky2016AlternativePO,
  title={Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.},
  author={Sandra Paschkowsky and Mehdi Hamz{\'e} and Felix Oestereich and Lisa Marie Munter},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 42},
  pages={21903-21912}
}
The amyloid precursor protein (APP) is an ubiquitously expressed cell surface protein and a key molecule in the etiology of Alzheimer disease. Amyloidogenic processing of APP through secretases leads to the generation of toxic amyloid β (Aβ) peptides, which are regarded as the molecular cause of the disease. We report here an alternative processing pathway of APP through the mammalian intramembrane rhomboid protease RHBDL4. RHBDL4 efficiently cleaves APP inside the cell, thus bypassing APP from… CONTINUE READING
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