Corpus ID: 83922004

Alternative Nf-kb Signaling in Atherogenesis

  title={Alternative Nf-kb Signaling in Atherogenesis},
  author={S. D{\"u}hring},


NF-kappaB regulation in the immune system.
The role of NF-kappaB proteins as potential therapeutic targets in clinical applications and their role in the immune system and inflammatory diseases are discussed. Expand
Cardiovascular disease risk factors: epidemiology and risk assessment.
  • B. Dahlöf
  • Medicine
  • The American journal of cardiology
  • 2010
The recently published Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) study, which showed that tel Misartan was as effective as ramipril in the prevention of a range of cardiovascular outcomes, enrolled a broad cross section of high-risk patients. Expand
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide.
This study identifies NF-kappaB target genes, reveals how the different NF- kappaB proteins coordinate their activity, and provides an initial map of the transcriptional regulatory network that underlies the host response to infection. Expand
Introduction to NF-κB: players, pathways, perspectives
An overview of the discovery and current status of NF-κB as a research topic is provided and the organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-σB. Expand
Progress and challenges in translating the biology of atherosclerosis
Understanding how to combine experimental and clinical science will provide further insight into atherosclerosis and could lead to new clinical applications. Expand
Progress and challenges in translating the biology of atherosclerosis." Nature
  • 2011
The immune system in atherosclerosis
Innate as well as adaptive immune responses have been identified in atherosclerosis, with components of cholesterol-carrying low-density lipoprotein triggering inflammation, T cell activation and antibody production during the course of disease. Expand
Dichotomy between factors inducing the immunosuppressive enzyme IL‐4‐induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes
It is proposed that IL4I1 participates in the downregulation of Th1 inflammation in vivo, as it is shown that the expression of IL4i1 by a monocytic cell line inhibits T‐cell proliferation and production of IFN‐γ and inflammatory cytokines. Expand
Matrigel: A complex protein mixture required for optimal growth of cell culture
The ability to identify the low mass and abundance components of Matrigel illustrates the utility of this method for the analysis of the extracellular matrix, as well as the complexity of the matrix itself. Expand
Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)*
Activation of the alternative NFκB pathway is identified as a TNF signaling effect that can be specifically assigned to TNFR2 and membrane TNF. Expand