Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.

@article{Newman2015AlternativeNP,
  title={Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.},
  author={Erika A. Newman and Fujia Lu and Daniela Bashllari and Anthony Opipari and Valerie P. Castle},
  journal={Molecular cancer research : MCR},
  year={2015},
  volume={13 3},
  pages={
          470-82
        }
}
UNLABELLED In neuroblastoma, MYCN genomic amplification and segmental chromosomal alterations including 1p or 11q loss of heterozygocity and/or 17q gain are associated with progression and poor clinical outcome. Segmental alterations are the strongest predictor of relapse and result from unbalanced translocations attributable to erroneous repair of chromosomal breaks. Although sequence analysis of affected genomic regions suggests that these errors arise by nonhomologous end-joining (NHEJ) of… CONTINUE READING

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Overall genomic pattern is a predictor of outcome in neuroblastoma.

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