Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes*

Abstract

Poly(ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear protein that binds chromatin and catalyzes the transfer of ADP-ribose groups to itself and to numerous target proteins upon interacting with damaged DNA. The molecular basis for the dual role of PARP-1 as a chromatin architectural protein and a first responder in DNA repair pathways remains… (More)

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Cite this paper

@inproceedings{Clark2012AlternativeMO, title={Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes*}, author={Nicholas J Clark and Michael Kramer and Uma M. Muthurajan and Karolin Luger}, booktitle={The Journal of biological chemistry}, year={2012} }