Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.


Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activation of resident hepatic macrophages potentiates insulin resistance, the functions of alternatively activated Kupffer cells in metabolic disease remain unknown. Here we show that in response to the Th2… (More)
DOI: 10.1016/j.cmet.2008.04.003


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