Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

@article{Odegaard2008AlternativeMA,
  title={Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.},
  author={Justin I. Odegaard and Roberto Rafael Ricardo-Gonzalez and Alex Red Eagle and Divya Vats and Christine R. Morel and Matthew H. Goforth and Vidya Subramanian and Lata Mukundan and Anthony W. Ferrante and Ajay Chawla},
  journal={Cell metabolism},
  year={2008},
  volume={7 6},
  pages={496-507}
}
Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activation of resident hepatic macrophages potentiates insulin resistance, the functions of alternatively activated Kupffer cells in metabolic disease remain unknown. Here we show that in response to the Th2 cytokine interleukin-4 (IL-4), peroxisome proliferator-activated receptor delta (PPARdelta) directs expression of the alternative phenotype in… CONTINUE READING
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