Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

@article{Chen2005AlternativeGG,
  title={Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.},
  author={Min Chen and Oksana Gavrilova and Jie Liu and Tao Xie and Chu-Xia Deng and Annie T Nguyen and Lisa Marie Nackers and Javier Lorenzo and Laura Shen and Lee S. Weinstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 20},
  pages={7386-91}
}
Gnas is an imprinted gene with multiple gene products resulting from alternative splicing of different first exons onto a common exon 2. These products include stimulatory G protein alpha-subunit (G(s)alpha), the G protein required for receptor-stimulated cAMP production; extralarge G(s)alpha (XLalphas), a paternally expressed G(s)alpha isoform; and neuroendocrine-specific protein (NESP55), a maternally expressed chromogranin-like protein. G(s)alpha undergoes tissue-specific imprinting, being… CONTINUE READING