Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses*

@article{Balzano2015AlternativeAM,
  title={Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses*},
  author={Deborah Balzano and Mohamad-Ali Fawal and J. V. Vel{\'a}zquez and C. Santiveri and Joshua Yang and J. Pastor and R. Campos-Olivas and N. Djouder and D. Lietha},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={290},
  pages={24975 - 24985}
}
Background: Protein Kinase B (PKB) phosphorylates many targets to induce various cellular responses. Results: Whereas some regulatory features of PKB control intrinsic kinase activity, others regulate substrate specificity. Conclusion: PKB activation in the cytosol or via membrane targeting trigger distinct downstream signals. Significance: These data are important to develop therapeutics that selectively target specific branches of PKB signaling. Protein kinase B (PKB/Akt) is an important… Expand
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