Alternative 2-keto acid oxidoreductase activities in Trichomonas vaginalis.

  title={Alternative 2-keto acid oxidoreductase activities in Trichomonas vaginalis.},
  author={David M. Brown and J. A. Upcroft and Helen N Dodd and Nanhua Chen and P. Upcroft},
  journal={Molecular and biochemical parasitology},
  volume={98 2},
We have induced high levels of resistance to metronidazole (1 mM or 170 microg ml(-1)) in two different strains of Trichomonas vaginalis (BRIS/92/STDL/F1623 and BRIS/92/STDL/B7708) and have used one strain to identify two alternative T. vaginalis 2-keto acid oxidoreductases (KOR) both of which are distinct from the already characterised pyruvate:ferredoxin oxidoreductase (PFOR). Unlike the characterised PFOR which is severely down-regulated in metronidazole-resistant parasites, both of the… CONTINUE READING
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