Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology.

@article{Rhinn2012AlternativeT,
  title={Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology.},
  author={Herve Rhinn and Liang Qiang and Toru Yamashita and David Rhee and Ari Zolin and William B. Vanti and Asa Abeliovich},
  journal={Nature communications},
  year={2012},
  volume={3},
  pages={
          1084
        }
}
α-Synuclein is implicated both in physiological functions at neuronal synaptic terminals as well as in pathological processes in the context of Parkinson's disease. However, the molecular mechanisms for these apparently diverse roles are unclear. Here we show that specific RNA transcript isoforms of α-synuclein with an extended 3' untranslated region, termed aSynL, appear selectively linked to pathological processes, relative to shorter α-synuclein transcripts. Common variants in the aSynL 3… CONTINUE READING
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