Alternation of inwardly rectifying background K+ channel during development of rat fetal cardiomyocytes.

@article{Nagashima2001AlternationOI,
  title={Alternation of inwardly rectifying background K+ channel during development of rat fetal cardiomyocytes.},
  author={Masato Nagashima and Noritsugu Tohse and Kensuke Kimura and Yoichi Yamada and Nobuharu L. Fujii and Hideyo Yabu},
  journal={Journal of molecular and cellular cardiology},
  year={2001},
  volume={33 3},
  pages={
          533-43
        }
}
The resting membrane potential of rat ventricular myocytes dramatically hyperpolarizes in the late phase of the fetal period. In order to investigate the mechanisms of this hyperpolarization, we examined the electrophysiological properties and molecular structure of the inwardly rectifying background K+ channels of rat fetal ventricular myocytes. In a patch-clamp experiment the whole-cell current of the inwardly rectifying background K+ channel increased 12-fold from between 12 and 18 days… CONTINUE READING

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