Alternating conduction in the ischaemic border zone as precursor of reentrant arrhythmias: a simulation study.

  title={Alternating conduction in the ischaemic border zone as precursor of reentrant arrhythmias: a simulation study.},
  author={Olivier Bernus and Christian W. Zemlin and Roman M Zaritsky and S. F. Mironov and Arkady M. Pertsov},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  volume={7 Suppl 2},
AIMS Here, we investigate the mechanisms underlying the onset of conduction-related arrhythmias in a three-dimensional (3D) computational model of acute regional ischaemia. METHODS Ischaemia was introduced by realistic gradients of potassium, pH, oxygen and electrical coupling in a 3D slab of ventricular tissue using the LRd model. We focused on a specific stage (10-15 min after occlusion) at which an intramural non-conductive ischaemic core (IC) surrounded by a border zone (BZ) has formed… CONTINUE READING

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