Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex.

@article{Skowron1993AlternatingAI,
  title={Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex.},
  author={Gall Skowron and Samuel A. Bozzette and Louis Lim and C B Pettinelli and Herbert H. Schaumburg and Joseph Arezzo and Margaret A Fischl and William G. Powderly and David J. Gocke and Douglas D. Richman and John C. Pottage and D Antoniskis and Gavin McKinley and Newton E Hyslop and Gabrielle Ray and Giorgio Simon and Nathaniel Reed and Marsha L. LoFaro and R B Uttamchandani and Lawrence D Gelb and Steven Sperber and R. L. Murphy and John M. Leedom and Maria Grieco and John Zachary and Martin S. Hirsch and Steven A Spector and Joseph Bigley and W J Soo and Thomas C. Merigan},
  journal={Annals of internal medicine},
  year={1993},
  volume={118 5},
  pages={321-30}
}
Zidovudine is a nucleoside analog that reduces progression of human immunodeficiency virus type 1 (HIV)-associated disease and prolongs survival [1-3]. The use of this drug at high doses in patients with advanced disease has been limited by hematologic toxicity [4-6]. Initial studies of another nucleoside analog, 2,3-dideoxycytidine (ddC), have shown that it is a potent inhibitor of HIV replication; therapy with ddC results in both the rapid suppression of serum p24 antigen levels and increases… CONTINUE READING

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2',3'-dideoxycytidine (ddC) in the treatment of patients with AIDS and ARC [Abstract

  • M Gottlieb, J Galpin, J Thompkins, D Wilson, L Donatacci, W. Soo
  • Proceedings of the Fifth International Conference…
  • 1989
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