Alternate strategies in lesion-induced reactive synaptogenesis: differential expression of L1 in two populations of sprouting axons.

@article{Styren1995AlternateSI,
  title={Alternate strategies in lesion-induced reactive synaptogenesis: differential expression of L1 in two populations of sprouting axons.},
  author={Scott D Styren and Peteryne D. Miller and Carl F. Lagenaur and Steven DeKosky},
  journal={Experimental neurology},
  year={1995},
  volume={131 2},
  pages={165-73}
}
In the CNS the cell adhesion molecule L1 plays a role in axonal growth and fasciculation. Since its roles in synapse formation and CNS regeneration are unknown, we followed the staining of L1 through the sequence of degeneration and reactive axon sprouting in the denervated outer molecular layer (ML) of the hippocampal dentate gyrus following ipsilateral entorhinal cortex (ERC) lesion. We compared immunohistological and ultrastructural localization of L1 and employed image analysis to evaluate… CONTINUE READING
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