Alternate stoichiometries of 4 2 nicotinic acetylcholine receptors

@inproceedings{Nelson2003AlternateSO,
  title={Alternate stoichiometries of 4 2 nicotinic acetylcholine receptors},
  author={Mark E Nelson and Alexander Kuryatov and Catherine H. Choi and Yan Zhou and John. Lindstrom},
  year={2003}
}
Two functional types of nicotinic acetylcholine receptors (nAChRs) are expressed when human embryonic kidney cells are permanently transfected with equal amounts of human 4 and 2 subunit cDNAs. Most (82%) of these nAChRs exhibit an EC50 of 74 6 M for ACh, a much lower sensitivity than the remaining fraction (EC50 of 0.7 0.4 M) or than expected from expression of equal amounts of 4 and 2 mRNAs in Xenopus laevis oocytes. We have found three conditions that can increase the number of nAChRs with… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 104 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Similar Papers

Loading similar papers…