Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.

@article{Luo1999AlternateCO,
  title={Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.},
  author={Xiang Luo and Wei-sen Zeng and Xiang Xu and Serguei Popov and Isabelle Davignon and Thomas M. Wilkie and Susanne M Mumby and Shmuel Muallem},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 25},
  pages={17684-90}
}
Many Gs-coupled receptors can activate both cAMP and Ca2+ signaling pathways. Three mechanisms for dual activation have been proposed. One is receptor coupling to both Gs and G15 (a Gq class heterotrimeric G protein) to initiate independent signaling cascades that elevate intracellular levels of cAMP and Ca+2, respectively. The other two mechanisms involve cAMP-dependent protein kinase-mediated activation of phospholipase Cbeta either directly or by switching receptor coupling from Gs to Gi… CONTINUE READING
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