Alternate chromogens as substitutes for benzidine for myeloperoxidase cytochemistry.

@article{Sheibani1981AlternateCA,
  title={Alternate chromogens as substitutes for benzidine for myeloperoxidase cytochemistry.},
  author={K. Sheibani and Fred V. Lucas and Raymond R. Tubbs and Roytesa Savage and Gerald A. Hoeltge},
  journal={American journal of clinical pathology},
  year={1981},
  volume={75 3},
  pages={367-70}
}
Myeloperoxidase staining methods for classification of leukemias have traditionally employed benzidine dihydrochloride as the chromogen. Recent Occupational Safety and Health Administration regulations have classified benzidine as a carcinogen, which severely restricts its use in the clinical laboratory. Twenty-two specimens from normal control subjects and leukemia patients, previously classified by FAB criteria, were stained with benzidine and two alternate chromogens, diaminobenzidine and… CONTINUE READING