Alternate centromere inactivation in a pseudodicentric (15;20)(pter;pter) associated with a progressive neurological disorder.

@article{Rivera1989AlternateCI,
  title={Alternate centromere inactivation in a pseudodicentric (15;20)(pter;pter) associated with a progressive neurological disorder.},
  author={Horacio Rivera and Orsetta Zuffardi and Paola Maraschio and Angela Caiulo and Cecilia Anichini and Rui Gureghian Scarinci and Rossella Vivarelli},
  journal={Journal of medical genetics},
  year={1989},
  volume={26 10},
  pages={626-30}
}
A 13 year old male with a severe progressive neurological disorder was found to have a pseudodicentric chromosome resulting from a telomeric fusion 15p;20p. In lymphocytes, the centromeric constriction of the abnormal chromosome was always that of the chromosome 20, while in fibroblasts both centromeres were alternately constricted. Cd staining was positive only at the active centromere, but a weak anticentromere immunofluorescence was present at the inactive one. We suggest that centromere… CONTINUE READING

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