Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.

@article{Doherty2012AlternariaIS,
  title={Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.},
  author={Taylor A. Doherty and Naseem Khorram and Kotaro Sugimoto and Dean Sheppard and Peter Rosenthal and Jae Youn Cho and Alexa K Pham and Marina D Miller and Michael Croft and David H. Broide},
  journal={Journal of immunology},
  year={2012},
  volume={188 6},
  pages={2622-9}
}
The fungal allergen, Alternaria, is specifically associated with severe asthma, including life-threatening exacerbations. To better understand the acute innate airway response to Alternaria, naive wild-type (WT) mice were challenged once intranasally with Alternaria. Naive WT mice developed significant bronchoalveolar lavage eosinophilia following Alternaria challenge when analyzed 24 h later. In contrast to Alternaria, neither Aspergillus nor Candida induced bronchoalveolar lavage eosinophilia… CONTINUE READING
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