Alternaria-Induced Release of IL-18 from Damaged Airway Epithelial Cells: An NF-κB Dependent Mechanism of Th2 Differentiation?

@inproceedings{Murai2012AlternariaInducedRO,
  title={Alternaria-Induced Release of IL-18 from Damaged Airway Epithelial Cells: An NF-κB Dependent Mechanism of Th2 Differentiation?},
  author={Hiroki Murai and Huibin Qi and Barun Choudhury and Jim Wild and Nilesh G Dharajiya and Swapnil V. Vaidya and Anjana Kalita and Attila Bacsi and David Corry and Alexander Kurosky and Allan R. Brasier and Istvan Boldogh and Sanjiv Sur},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND A series of epidemiologic studies have identified the fungus Alternaria as a major risk factor for asthma. The airway epithelium plays a critical role in the pathogenesis of allergic asthma. These reports suggest that activated airway epithelial cells can produce cytokines such as IL-25, TSLP and IL-33 that induce Th2 phenotype. However the epithelium-derived products that mediate the pro-asthma effects of Alternaria are not well characterized. We hypothesized that exposure of the… CONTINUE READING

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Alternaria extract activates autophagy that induces IL-18 release from airway epithelial cells.

  • Biochemical and biophysical research communications
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