Altering the insertional specificity of a Drosophila transposable element.

  title={Altering the insertional specificity of a Drosophila transposable element.},
  author={Judith A. Kassis and Else Noll and E P VanSickle and Ward F Odenwald and Norbert Perrimon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 5},
Vectors derived from the Drosophila P element transposon are widely used to make transgenic Drosophila. Insertion of most P-element-derived vectors is nonrandom, but they exhibit a broad specificity of target sites. During experiments to identify cis-acting regulatory elements of the Drosophila segmentation gene engrailed, we identified a fragment of engrailed DNA that, when included within a P-element vector, strikingly alters the specificity of target sites. P-element vectors that contain… CONTINUE READING

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