Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth.

@article{Hinton1995AlteringTE,
  title={Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth.},
  author={David A. Hinton and Susan C. Evans and Barry D. Shur},
  journal={Experimental cell research},
  year={1995},
  volume={219 2},
  pages={640-9}
}
beta 1,4-Galactosyltransferase (GalTase) is unusual among the glycosyltransferases in that it is localized both in the Golgi complex and on the cell surface. Most studies of surface GalTase function have focused on its role in cellular interactions; however, surface GalTase has also been suggested to function during cellular proliferation. Consistent with this hypothesis, a variety of GalTase-specific perturbants inhibit cell growth in vitro and in vivo. However, all of these studies have been… CONTINUE READING

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