Altering mitochondrial dysfunction as an approach to treating Alzheimer's disease.

@article{Colca2012AlteringMD,
  title={Altering mitochondrial dysfunction as an approach to treating Alzheimer's disease.},
  author={Jerry Raymond Colca and Douglas L Feinstein},
  journal={Advances in pharmacology},
  year={2012},
  volume={64},
  pages={155-76}
}
Mitochondrial dysfunction appears to be a precipitating or exacerbating factor in both familial and late stage Alzheimer's disease. This chapter summarizes various mechanisms by which dysfunction of mitochondrial metabolism can be involved in loss of cognitive function as well as in the exacerbation of structural changes in the signature pathology of Alzheimer's disease. Although currently few in number, a number of mitochondrially directed/metabolic approaches are now being tried that include… CONTINUE READING
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Mitochondria-derived ROS lead to enhanced amyloid beta formation

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