Altering Metabolic Profiles of Drugs by Precision Deuteration : Reducing Mechanism-Based Inhibition of CYP 2 D 6 by Paroxetine s

@inproceedings{Uttamsingh2015AlteringMP,
  title={Altering Metabolic Profiles of Drugs by Precision Deuteration : Reducing Mechanism-Based Inhibition of CYP 2 D 6 by Paroxetine s},
  author={Vinita Uttamsingh and Richard Gallegos and Julie F. Liu and Scott L. Harbeson and Gary W. Bridson and Changfu Cheng and David S. Wells and Philip B. Graham and Robert Zelle and Roger D. Tung},
  year={2015}
}
Selective deuterium substitution as ameans of ameliorating clinically relevant pharmacokinetic drug interactions is demonstrated in this study. Carbon-deuterium bonds are more stable than corresponding carbon-hydrogen bonds. Using a precision deuteration platform, the two hydrogen atoms at the methylenedioxy carbon of paroxetine were substituted with… CONTINUE READING