Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid.

@article{Bui1998AlteredZM,
  title={Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid.},
  author={Linh M. Bui and Marie W. Taubeneck and Joel F Commisso and Janet Y. Uriu-Hare and Willem D Faber and Carl L. Keen},
  journal={Toxicology},
  year={1998},
  volume={126 1},
  pages={9-21}
}
It has been hypothesized that the developmental toxicity of certain compounds is, in part, due to maternal toxicity resulting in alterations in zinc (Zn) metabolism that affects the developing conceptus. In the present work the effects of developmentally toxic doses of 2-ethylhexanoic acid (EHXA), 2-ethylhexanol (EHXO), and valproic acid (VPA) on Zn metabolism were investigated in the pregnant rat. In experiment 1, dams were intubated with EHXA (3.13, 6.25, 9.38 or 12.5 mmol/kg), EHXO (6.25, 9… CONTINUE READING

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