Altered xanthine oxidase and N-acetyltransferase activity in obese children.

@article{Chiney2011AlteredXO,
  title={Altered xanthine oxidase and N-acetyltransferase activity in obese children.},
  author={Manoj S Chiney and Sarah Jane Schwarzenberg and L'aurelle A Johnson},
  journal={British journal of clinical pharmacology},
  year={2011},
  volume={72 1},
  pages={109-15}
}
AIMS It is well established that oxidative and conjugative enzyme activity differs between obese and healthy-weight adults. However, the effect of obesity on drug metabolism in children has not been studied extensively. This study examined whether obese and healthy-weight children vary with respect to oxidative enzyme activity of CYP1A2, xanthine oxidase (XO) and conjugative enzyme activity of N-acetyltransferase 2 (NAT2). METHODS In vivo CYP1A2, XO and NAT2 activity was assessed in obese (n… CONTINUE READING

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