Altered white and gray matter metabolism in CADASIL: a proton MR spectroscopy and 1H-MRSI study.


OBJECTIVE Subcortical white matter hyperintensities (WMH) and small cystic lesions are the radiologic hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy causing stroke in young adults. To further characterize the cerebral pathology in vivo we analyzed metabolite… (More)


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