Altered water diffusivity in cortical association tracts in children with early deprivation identified with Tract-Based Spatial Statistics (TBSS).
@article{Govindan2010AlteredWD, title={Altered water diffusivity in cortical association tracts in children with early deprivation identified with Tract-Based Spatial Statistics (TBSS).}, author={Rajkumar Munian Govindan and Michael E. Behen and Emily J. Helder and Malek I Makki and Harry T. Chugani}, journal={Cerebral cortex}, year={2010}, volume={20 3}, pages={ 561-9 } }
Institutional rearing is associated with neurocognitive and behavioral difficulties. Although such difficulties are thought to reflect abnormal neurologic development resulting from early social deprivation (ED) and there is evidence for functional abnormality in children with histories of ED, the impact of early deprivation on brain anatomy has received little study in humans. The present study utilized an objective and sensitive neuroimaging analysis technique (Tract-Based Spatial Statistics…
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References
SHOWING 1-10 OF 80 REFERENCES
Abnormal Brain Connectivity in Children After Early Severe Socioemotional Deprivation: A Diffusion Tensor Imaging Study
- Psychology, MedicinePediatrics
- 2006
This study demonstrates in children who experienced socioemotional deprivation a structural change in the left uncinate fasciculus that partly may underlie the cognitive, socioem emotional, and behavioral difficulties that commonly are observed in these children.
Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents.
- PsychologyCerebral cortex
- 2007
Whole-brain diffusion tensor tractography (DTT) at high signal-to-noise ratio and angular and spatial resolutions were utilized to study the effects of age, sex differences, and lateral asymmetries…
Diffusion tensor imaging reveals white matter reorganization in early blind humans.
- Psychology, MedicineCerebral cortex
- 2006
It is suggested that blindness leads to a reorganization of cerebral WM and plausibly support the hypothesis that visual cortex functionality in blindness is primarily mediated by corticocortical as opposed to thalamocorticals connections.
Regional DTI differences in multiple sclerosis patients
- Medicine, PsychologyNeuroImage
- 2009
Fast quantitative diffusion-tensor imaging of cerebral white matter from the neonatal period to adolescence
- MedicineNeuroradiology
- 2003
There is a trend to continuous increase in FA in all deep white-matter areas, suggesting continuing maturation and organisation of deep tracts not detected on conventional MRI.
Frontal connections and cognitive changes in normal aging rhesus monkeys: A DTI study
- Biology, PsychologyNeurobiology of Aging
- 2007
Abnormal diffusion of cerebral white matter in early blindness
- MedicineHuman brain mapping
- 2009
It is suggested that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind.
Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis
- Medicine, BiologyNeuroImage
- 2008
Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis
- Biology, PsychologyNeuroImage
- 2009
Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans
- Psychology, BiologyNeuroImage
- 2001
Dysfunction of these brain regions may result from the stress of early global deprivation and may be involved in the long-term cognitive and behavioral deficits displayed by some Romanian orphans.