Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes

@article{Basselin1997AlteredTP,
  title={Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes},
  author={Mireille Basselin and Françoise Lawrence and Malka Robert-Gero},
  journal={Parasitology Research},
  year={1997},
  volume={83},
  pages={413-418}
}
Pentamidine-resistant clones of Leishmania donovani and L. amazonensis promastigotes were developed by increase of the drug pressure in the culture medium and characterized. The resistant clones could grow in 40 and 20 μM pentamidine as determined for L.␣donovani and L. amazonensis, respectively, with 50% inhibitory concentrations (IC50 values) being 140 and 60 μM, which were 18 and 75 times higher than those recorded for the parental clones, respectively. Biochemical analysis of the clones… CONTINUE READING

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