Altered transcription factor E3 expression in unclassified adult renal cell carcinoma indicates adverse pathological features and poor outcome.

@article{Mir2011AlteredTF,
  title={Altered transcription factor E3 expression in unclassified adult renal cell carcinoma indicates adverse pathological features and poor outcome.},
  author={Maria Carmen Mir and Enrique Trilla and Ines Maria de Torres and A. Panizo and Alexander R Zlotta and Bas van Rhijn and J M S{\'a}nchez Morote},
  journal={BJU international},
  year={2011},
  volume={108 2 Pt 2},
  pages={E71-6}
}
OBJECTIVES To evaluate the clinical and pathologic features and the prognostic relevance of unclassified RCC with -TFE3 over-expression in our adult series. Recent studies suggest that renal cell carcinomas (RCCs) associated with the newly recognized Xp11.2 translocation (transcription factor E3 [TFE3] gene fusions) can be found among adults with RCC showing a very aggressive disease-course. MATERIAL AND METHODS We evaluated tumour specimens from 25 patients with unclassified RCC morphology… CONTINUE READING