Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.

@article{Schmitz1999AlteredTJ,
  title={Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.},
  author={Heinz Schmitz and Christian Barmeyer and Michael Fromm and Norbert Runkel and Hanne Foss and Carl J. Bentzel and E. O. Riecken and J{\"o}rg-Dieter Schulzke},
  journal={Gastroenterology},
  year={1999},
  volume={116 2},
  pages={301-9}
}
BACKGROUND & AIMS Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and transport properties in ulcerative colitis (UC) was performed. METHODS Inflamed sigmoid colon epithelium from UC patients was studied by alternating current impedance analysis to determine the pure epithelial resistance as a measure of intestinal barrier function. Tight junction (TJ) structure was investigated by freeze-fracture electron… CONTINUE READING

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