Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.

@article{Trojanowski1993AlteredTA,
  title={Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.},
  author={J. Q. Trojanowski and Marie Luise Schmidt and R. W. Shin and G T Bramblett and D. Sharath Babu Rao and V M.-Y. Lee},
  journal={Brain pathology},
  year={1993},
  volume={3 1},
  pages={45-54}
}
The neuronal cytoskeleton is one of the most profoundly altered organelles in late life neuro-degenerative disorders that are characterized by progressive impairments in cognitive abilities. The elucidation of the protein building blocks of these organelles as well as advances in understanding how these proteins become altered in Alzheimer's disease (AD) and other less common dementing illnesses, i.e., diffuse Lewy body disease (DLBD) or the Lewy body variant of AD (LBVAD), will provide… CONTINUE READING

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