Altered target gene regulation controlled by estrogen receptor-alpha concentration.

@article{Fowler2006AlteredTG,
  title={Altered target gene regulation controlled by estrogen receptor-alpha concentration.},
  author={Amy M. Fowler and Natalia M. Solodin and Christopher Carlin Valley and Elaine T. Alarid},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 2},
  pages={
          291-301
        }
}
Estrogen receptor-alpha (ERalpha) is a transcriptional activator whose concentration is tightly regulated by the cellular environment. In breast tumors of postmenopausal women, elevated receptor concentrations can be associated with negative clinical outcomes, yet it remains poorly understood how such high levels impact ERalpha function. We previously demonstrated that high nuclear concentrations of ERalpha in breast cancer cells bypass the requirement for ligand and are sufficient to activate… CONTINUE READING

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