Altered synaptic plasticity in a mouse model of fragile X mental retardation.

  title={Altered synaptic plasticity in a mouse model of fragile X mental retardation.},
  author={Kimberly M Huber and Sean M Gallagher and Stephen T Warren and Mark F. Bear},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 11},
Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). Biochemical evidence indicates that FMRP binds a subset of mRNAs and acts as a regulator of translation. However, the consequences of FMRP loss on neuronal function in mammals remain unknown. Here we show that a form of protein synthesis-dependent synaptic plasticity, long-term depression triggered by activation of… CONTINUE READING
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