Altered synaptic function in Alzheimer's disease.

  title={Altered synaptic function in Alzheimer's disease.},
  author={Karen F. S. Bell and A Claudio Cuello},
  journal={European journal of pharmacology},
  volume={545 1},
Alzheimer's disease is the leading cause of dementia in the elderly, presenting itself clinically by progressive loss of memory and learning. Since synaptic density correlates more closely with cognitive impairment than any other pathological lesion observable in the disease pathology, an increased understanding of the mechanisms behind synaptic disconnection is of vital importance. Our lab investigated the neurotransmitter-specific status of distinct cortical presynaptic bouton populations in… CONTINUE READING

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