Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model.

@article{Setton1993AlteredSR,
  title={Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model.},
  author={Lori A. Setton and Van C. Mow and Francisco J. Muller and Julio Ch{\'a}vez Pita and David S. Howell},
  journal={Agents and actions. Supplements},
  year={1993},
  volume={39},
  pages={
          27-48
        }
}
A review of the structure-function relationships for normal articular cartilage is provided. This provides the foundation for understanding the roles played by collagen, proteoglycan and water in determining the material properties of the tissue. A summary of biomechanical and compositional changes in human osteoarthritic cartilage is also presented. Finally, the results from our recent interdisciplinary study on an experimental osteoarthritis model is described, and new hypotheses are proposed… CONTINUE READING

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