Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.

  title={Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.},
  author={Mark Schaefer and Scott T. Wong and David F. Wozniak and Lisa M. Muglia and Jason Liauw and Min Zhuo and Anthony R. Nardi and Richard E Hartman and Sherri K. Vogt and Christina E. Luedke and Daniel R Storm and Louis J. Muglia},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 13},
Stress results in alterations in behavior and physiology that can be either adaptive or maladaptive. To define the molecular pathways involved in the response to stress further, we generated mice deficient (KO) in the calcium-stimulated adenylyl cyclase type VIII (AC8) by homologous recombination in embryonic stem cells. AC8 KO mice demonstrate a compromise in calcium-stimulated AC activity in the hippocampus, hypothalamus, thalamus, and brainstem. Hippocampal slices derived from AC8 KO mice… CONTINUE READING
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