Altered sterol composition renders yeast thermotolerant

  title={Altered sterol composition renders yeast thermotolerant},
  author={Luis Caspeta and Yun Chen and Payam Ghiaci and Amir Feizi and Steen Buskov and Bj{\"o}rn Mikael Hallstr{\"o}m and Dina Petranovic and Jens Nielsen},
Ethanol production for use as a biofuel is mainly achieved through simultaneous saccharification and fermentation by yeast. Operating at ≥40°C would be beneficial in terms of increasing efficiency of the process and reducing costs, but yeast does not grow efficiently at those temperatures. We used adaptive laboratory evolution to select yeast strains with improved growth and ethanol production at ≥40°C. Sequencing of the whole genome, genome-wide gene expression, and metabolic-flux analyses… CONTINUE READING
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Materials and methods are available on Science Online 14

  • J. R. Dettman
  • Nature
  • 1981

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