Altered spatial calcium regulation enhances electrical heterogeneity in the failing canine left ventricle: implications for electrical instability.


Myocytes across the left ventricular (LV) wall of the mammalian heart are known to exhibit heterogeneity of electrophysiological properties; however, the transmural variation of cellular electrophysiology and Ca(2+) homeostasis in the failing LV is incompletely understood. We studied action potentials (APs), the L-type calcium (Ca(2+)) current (I(Ca,L… (More)
DOI: 10.1152/japplphysiol.00609.2011

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