Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study.

@article{Hennebelle2017AlteredSE,
  title={Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study.},
  author={Marie Hennebelle and Yurika Otoki and Jun Yang and Bruce D Hammock and Anthony J. Levitt and Ameer Y Taha and Walter Swardfager},
  journal={Psychiatry research},
  year={2017},
  volume={252},
  pages={94-101}
}
Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck… CONTINUE READING

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We conclude that winter depression was associated with changes in cytochrome p450- and sEH - derived oxylipins , suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD - s .
We conclude that winter depression was associated with changes in cytochrome p450- and sEH - derived oxylipins , suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD - s .
We conclude that winter depression was associated with changes in cytochrome p450- and sEH - derived oxylipins , suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD - s .
We conclude that winter depression was associated with changes in cytochrome p450- and sEH - derived oxylipins , suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD - s .
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