Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

@article{Hains2004AlteredSC,
  title={Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.},
  author={Bryan C. Hains and Carl Y. Saab and Joshua P. Klein and Matthew J. Craner and Stephen G. Waxman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 20},
  pages={4832-9}
}
Peripheral nerve injury is known to upregulate the rapidly repriming Na(v)1.3 sodium channel within first-order spinal sensory neurons. In this study, we hypothesized that (1) after peripheral nerve injury, second-order dorsal horn neurons abnormally express Na(v)1.3, which (2) contributes to the responsiveness of these dorsal horn neurons and to pain… CONTINUE READING