Altered sleep and behavioral activity phenotypes in PER3-deficient mice.

@article{Hasan2011AlteredSA,
  title={Altered sleep and behavioral activity phenotypes in PER3-deficient mice.},
  author={Sibah Hasan and Daan R. van der Veen and Raphaelle Winsky-Sommerer and Derk-Jan Dijk and Simon N Archer},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={301 6},
  pages={
          R1821-30
        }
}
  • S. Hasan, D. R. van der Veen, +2 authors S. Archer
  • Published 1 December 2011
  • Biology, Psychology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Sleep homeostasis and circadian rhythmicity interact to determine the timing of behavioral activity. Circadian clock genes contribute to circadian rhythmicity centrally and in the periphery, but some also have roles within sleep regulation. The clock gene Period3 (Per3) has a redundant function within the circadian system and is associated with sleep homeostasis in humans. This study investigated the role of PER3 in sleep/wake activity and sleep homeostasis in mice by recording wheel-running… 
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A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism
  • S. Hasan, D. R. van der Veen, +5 authors S. Archer
  • Biology, Psychology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
TLDR
The hypothesis derived from human data that the PER3 VNTR polymorphism modifies the sleep homeostatic response without significantly influencing circadian parameters is believed to be correct.
Effects of circadian misalignment on sleep in mice
TLDR
The data show that circadian misalignment results in previously uncharacterised long-term effects on sleep, which may have important consequences for behaviour.
The sleep-wake distribution contributes to clock gene expression: a descriptive and a mechanistic study in mice
TLDR
This thesis supports the importance of considering the sleep-wake distribution when using clock gene expression as a state variable of the clock and demonstrates that CIRBP modulates the SD incurred changes in corticalClock gene expression and contributes to REM sleep recovery.
Circadian Chimeric Mice Reveal an Interplay Between the Suprachiasmatic Nucleus and Local Brain Clocks in the Control of Sleep and Memory
TLDR
A central role for the circadian clocks of SCN Drd1a cells in circadian sleep regulation is demonstrated, and a role for extra-SCN clocks is indicated in circumstances where the SCN and sub-ordinate local clocks are temporally mis-aligned.
Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits
TLDR
In clockless mice, circadian molecular competence focused solely on the SCN rescued the architecture and consolidation of sleep-wake and sleep-dependent memory, highlighting its dominant role in timing sleep.
ON THE ROLE OF PERIOD-2 IN THE CIRCADIAN AND HOMEOSTATIC REGULATION OF SLEEP
TLDR
The results demonstrate that sleep-wake history can affect the molecular clock machinery directly at the level of the chromatin thereby altering the cortical expression of Dbp and Per2, and likely other targets and suggest instead that the earlier onset of activity results from a labile, not-self sustained 22h rhythm linked to light onset.
Tissue-Specific Function of Period3 in Circadian Rhythmicity
TLDR
Investigating the role of Per3 in circadian timekeeping in central and peripheral oscillators by analyzing PER2::LUCIFERASE expression in tissues explanted from C57BL/6J wild-type and Per3−/− mice demonstrated that Per3 is a key player in the mammalian circadian system.
The molecular clockwork of the suprachiasmatic nucleus is sufficient to co-ordinate phasing and stabilisation of sleep-wake cycles and enhance memory deficits in a clockless mouse
TLDR
The SCN clock is sufficient for circadian control of sleep-wake, facilitating initiation and maintenance of wake, promoting sleep consolidation, homeostatic dynamics, and sleep-dependent memory.
Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation
TLDR
CIRBP adjusts cortical clock-gene expression after sleep deprivation and expedites REM-sleep recovery, and Unexpectedly, KO mice were more active during lights-off which was accompanied with faster theta oscillations compared to WT mice.
The circadian control of sleep.
TLDR
The role of clock genes in the regulation of sleep has attracted considerable interest, and here, an overview of the interplay between specific elements of the molecular clock with the sleep regulatory system is provided.
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