Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation.

@article{Bikle1994AlteredSP,
  title={Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation.},
  author={Daniel D Bikle and Jessica D Harris and Bernard P. Halloran and Emily R. Morey-Holton},
  journal={The American journal of physiology},
  year={1994},
  volume={267 6 Pt 1},
  pages={E822-7}
}
Spaceflight leads to osteopenia, in part by inhibiting bone formation. Using an animal model (hindlimb elevation) that simulates the weightlessness of spaceflight, we and others showed a reversible inhibition of bone formation and bone mineralization. In this study, we have measured the mRNA levels of insulin-like growth factor I (IGF-I), IGF-I receptor (IGF-IR), alkaline phosphatase, and osteocalcin in the tibiae of rats flown aboard National Aeronautics and Space Administration Shuttle Flight… CONTINUE READING