Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

@article{Siarey2006AlteredSP,
  title={Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.},
  author={Richard J. Siarey and Angelina Kline-Burgess and Madelaine Cho and Andrea Balbo and Tyler K. Best and Chie Harashima and Eric Klann and Zygmunt Galdzicki},
  journal={Journal of neurochemistry},
  year={2006},
  volume={98 4},
  pages={1266-77}
}
The Ts65Dn mouse model of Down syndrome (DS) has an extra segment of chromosome (Chr.) 16 exhibits abnormal behavior, synaptic plasticity and altered function of several signaling molecules. We have further investigated signaling pathways that may be responsible for the impaired hippocampal plasticity in the Ts65Dn mouse. Here we report that calcium/calmodulin-dependent protein kinase II (CaMKII), phosphatidylinositol 3-kinase (PI3K)/Akt, extracellular signal-regulated kinase (ERK), protein… CONTINUE READING

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