Altered self-assembly and apatite binding of amelogenin induced by N-terminal proline mutation.

@article{Zhu2011AlteredSA,
  title={Altered self-assembly and apatite binding of amelogenin induced by N-terminal proline mutation.},
  author={Li Zhu and Vuk Uskokovi{\'c} and Thuan Le and Pamela K Denbesten and Yulei Huang and Stefan Habelitz and Wesley Li},
  journal={Archives of oral biology},
  year={2011},
  volume={56 4},
  pages={
          331-6
        }
}
OBJECTIVE A single Pro-70 to Thr (p.P70T) mutation of amelogenin is known to result in hypomineralised amelogenesis imperfecta (AI). This study aims to test the hypothesis that the given mutation affects the self-assembly of amelogenin molecules and impairs their ability to conduct the growth of apatite crystals. DESIGN Recombinant human full-length wild-type (rh174) and p.P70T mutated amelogenins were analysed using dynamic light scattering (DLS), protein quantification assay and atomic… CONTINUE READING
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