Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1

@article{Studer1996AlteredSI,
  title={Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1},
  author={Mich{\`e}le Studer and Andrew G. S. Lumsden and Linda Ariza-McNaughton and Adrienne Bradley and Robb K Krumlauf},
  journal={Nature},
  year={1996},
  volume={384},
  pages={630-634}
}
SEGMENTATION of the vertebrate hindbrain into rhombomeres is important for the anterior–posterior arrangement of cranial motor nuclei and efferent nerves1. Underlying this reiterated organization, Hox genes display segmentally restricted domains of expression2–4, such as expression of Hoxb-1 (refs 5, 6) in rhombomere 4 (r4). Here we report that absence of Hoxb-1 leads to changes in r4 identity. In mutant mouse embryos, molecular markers indicate that patterning of r4 is initiated properly but… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 189 CITATIONS, ESTIMATED 55% COVERAGE

359 Citations

0102030'97'02'08'14
Citations per Year
Semantic Scholar estimates that this publication has 359 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…