Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain.

  title={Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain.},
  author={M. A. Cabajo Caballero and Laura Leigh S Rowlette and Teresa Borr{\'a}s},
  journal={Biochimica et biophysica acta},
  volume={1502 3},
TIGR/MYOC, a novel 504 amino acids (aa) protein of unknown function, has recently been linked to glaucoma. The protein is both intra- and extracellular and most known mutations map to its C-terminus, an olfactomedin-like domain. To investigate the properties of a TIGR/MYOC peptide lacking this important domain, we constructed a replication-deficient adenovirus with the first 344 aa and over-expressed the truncated protein in primary human trabecular meshwork cells and perfused human anterior… CONTINUE READING

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