Altered role of microtubules in asialoglycoprotein trafficking in developing liver.

@article{Kaufman1990AlteredRO,
  title={Altered role of microtubules in asialoglycoprotein trafficking in developing liver.},
  author={Stuart S Kaufman and Patrick Blain and Ji Hyeun Park and Dean J. Tuma},
  journal={The American journal of physiology},
  year={1990},
  volume={258 1 Pt 1},
  pages={G129-37}
}
Efficient receptor-mediated endocytosis of asialoglycoprotein by mature liver requires participation of microtubules that convey newly internalized ligand to lysosomes for degradation and receptor back to plasma membrane to continue endocytosis. To ascertain whether microtubular participation in asialoglycoprotein endocytosis is altered during development, we compared endocytosis of 125I-labeled asialoorosomucoid (ASOR) in neonatal rat hepatocytes to that in adult cells, with and without… CONTINUE READING