Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment.

@article{Hill2006AlteredRO,
  title={Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment.},
  author={Matthew Nicholas Hill and Jane C. Sun and Maric T L Tse and Boris B. Gorzalka},
  journal={The international journal of neuropsychopharmacology},
  year={2006},
  volume={9 3},
  pages={277-86}
}
This study examined the effects of long-term cannabinoid administration on the responsivity of 5-HT1A and 5-HT2A receptors, which have been implicated in depression. Animals received 12 d administration of the potent cannabinoid receptor agonist HU-210 (100 microg/kg), following which they were monitored on their behavioural, physiological and hormonal responses to a single challenge of a 5-HT1A and 5-HT2A receptor agonist, 8-OH-DPAT (0.3 mg/kg) and DOI (1 mg/kg) respectively. Chronic HU-210… CONTINUE READING